魏培坤

Pei-Kuen Wei

Education

  • Master and Ph.D., Department of Electric Engineering, National Taiwan University
    (1989,09-1994,01)
  • Bachelor, Department of Mechanic Engineering, National Taiwan University
    (1985-1989)

Research Fields

  • Research Fields
    (1) Near-Field Optics, Nano-Photonics and Related Techniques
    (2) Applications of Nanostructures in Biosensing, Bioimaging and Green-Energy Devices.

    Recent Research Topics：
    (1) Nano-Optical Microscopy and Lithography：
    Our group is devoted to developing super-resolution optical techniques by using near-field optics. We developed various kinds of near-field microscopes to study different important thin-film devices, such as organic/inorganic thin films for light emitting devices, metallic/transparent nanostructures for biosensing and lithography, and dielectric/plasmonic structures for integrated optics. All these near-field measurements were done by the home-build systems. We have several patents for the nano-probe fabrication and system (US/TW patents). More than 30 papers relate to the near-field optical measurement have published. We also applied the concept of super-resolution optics for photomask nanolithography. This technology is more suitable for mass-production and commercial use. We invented near-field lithographic methods by using near-field focusing effects in mesoscale structures. The resolution is smaller than /5 (Optics Letters, 32, 71-73 (2007), the aspect ratio of focusing profiles is high (App. Phys. Lett. 88, 10110 (2006); Opt. Lett. 34, 1867-1869 (2009)). We can make photonic bandgap patterns with any designed defects by a simple photolithographic process (Nanotechnology 17, 1333 (2006)). This method can also be applied for making 3D subwavelength structures (Optical Express 15, 677 (2007)).

    (2) Nano-Photonic Devices：
    (a) Nano-Biosensors： We first confirmed the propagation of gap plasmon in nanoslits using the combinational studies of near-field microscopy and FDTD method. This work was introduced by Photonics Spectra. The gap plasmon is resonant in the nanoslit cavity. It results in extraordinary transmissions of TM polarized light. We studied the sensing applications of surface plasmon mode and gap plasmon mode in periodic gold nanoslits (J. Biomedical Optics, 12(4), 044023 (2007)). The biosensor using gap plasmon resonance has a sensitivity one order of magnitude higher than that of the surface plasmon resonance (Biosensor and Bioelectronics 24, 210 (2008)). The gap plasmon-based sensors are especially useful for high-throughput detections and biochip-based devices. We successfully demonstrated microarray detections for real-time measurements of antigen-antibody and DNA-DNA interactions (Opt. Express 17, 23104 (2009); Small 6, 1900 (2010); Plasmonics (2011)). In addition to the gap plasmon sensor, we also developed nano-fiber based sensors (J. Biomedical Optics, 2006, 11, 014032). We successfully applied the nano-fiber to measure the refractive index in cytoplasm of living cells (Appl. Phys. Lett. 93, 173110 (2008)) and pH values (Opt. Lett., 35, 944 (2010)).
    (b) Green Energy Devices： We improved the efficiencies of light emitting devices/solar cells by using nanostructures. For conventional OLEDs, twice brightness enhancement was achieved by using the surface plasmon effects of gold nanowire arrays (Appl. Phys. Lett. 92, 013303 (2008)).The metallic nanostructures can also be used as transparent electrodes (Organ. Electron.12, 2011) for OLEDs and organic solar cells. Recently, we developed a more efficient and cost-effective way to enhance the light extraction by using antireflection effect of transparent nanopillars (Opt. Express, 19. A295 (2011), selected paper 1). We also developed some optical novel components by using extraordinary optical properties of nanostructures, such as giant birefringence in metallic nanoslit which can be used as ultra-thin wavelength plates (Appl. Phys. Lett. 95, 013105 (2009)).
  • Honors and Awards：
     Doctoral Thesis Award, Optical Society of Taiwan
     Distinguished Postdoctoral Scholars, Academia Sinica
     Publications selected as 2007, 2008, 2012 and 2013 Academia Sinica Significant Researches
     Investigator Award, 2015, Academia Sinica

    Students (main advisor)
     Wei-Lun Cheng, 2005 Optics and Photonics in Taiwan, Student Paper Award
     Kuang-Li Lee, 2007 Optics and Photonics in Taiwan, Student Best Post Award
     Shen-Yu Hsu, 2008 SID International Conference, Student Travel Grant (US$500)
     Chia-Wei Lee, 2008 International Conference on Laser Applications in Life Sciences (LAIS), Student Paper Award
     En-Hong Lin, 2009 Optics and Photonics in Taiwan, Student Paper Award
     Su-Hann Wu, 2009 Optics and Photonics in Taiwan, Student Paper Award
     Yu-Hsuan Ho, 2011 SID International Conference, Student Travel Grant (US$500)
     Su-Hann Wu, 2011 Optics and Photonics in Taiwan, Student Paper Award
     Yu-Hsuan Ho, 2013 SID International Conference, Student Travel Grant (US$500)
     Yu-Hsuan Ho, 2013 International Display Manufacturing Conference, Distinguished Paper Award.
     Kuang-Li Lee, Best Oral Presentation Award, 2016 BEST conference & International Symposium on Biotechnology and Bioengineering.
     Cheng-Chuan Chen, 2017, Poster Award, International conferences of surface plasmon polaritons (SPP8)


    News：
    1. Our research, “Giant Birefringence Induced by Plasmonic Nanoslit Arrays,” Appl. Phys. Lett. 95, 013105 (2009), was selected and reported in the Laser Focus World as one of the Accelerated Ingenuity in 2009.
    2. Our paper, "Size-Dependent Endocytosis of Gold Nanoparticles Studied by Three-Dimensional Mapping of Plasmonic Scattering Images" 2010, 8：33, J. Nanobiotechnology. (2010) was is a high access paper in Journal of Nanobiotechnology (Total accesses to this article since publication： 2197)
    3. Our paper, ”Sensitive Label-Free Biosensors by Using Gap Plasmons in Gold Nanoslits”, Biosensors and Bioelectronics 24, 210-215 (2008), was selected in the book “Chemical Sensors： Fundamental of Sensing Materials (2010)” with 2 pages introduction.
    4. The research, “Intensity sensitivity of gold nanostructures and its application for high-throughput biosensing,” Optics Express, 17 Issue 25, pp.23104-23113 (2009), was selected as significant research of Academia Sinica in 2010.
    5. The paper, ”Extraction enhancement in organic light emitting devices by using metallic nanowire arrays”, Appl. Phys. Lett. 92, 013303 (2008), was a top 20 download paper in Jan. issue (2008) of Appl. Phys. Lett. and was reported by the website (IOP), nanotechweb.org.
    6. The research, ”Two-Dimensional Refractive Index Profiling by Using Differential Near-Field Scanning Optical Microscopy”, Appl. Phys. Lett. 91, 061123 (2007), was introduced by the optical magazine, Photonics Spectra in 2010
    7. The research, “Fabrication of a close-packed hemispherical submicron lens array and its application in photolithography”, Optical Express, Vol. 15, Issue 11, pp. 6774-6783, (2007), was selected in significant researches of Academia Sinica (2007).
    8. The paper, ”Sensitive Biosensor Array by Using Surface Plasmon Resonance on Metallic NanoSlits”, J. Biomedical Optics, 12(4), 044023 (2007), was most a frequently downloaded paper in digital library and selected as top notch research in December, 2007.
    9. The paper, “Characterization and applications of single fluorescent nanodiamonds as cellular biomarkers” PNAS 104： 727-732 (2007), (collaborated with W. S. Fann in IAMS, academia sinica) was reported by news of Anal. Chem., 2007, 79, 1768.
    10. Many published papers were also selected by Virtual Journals such as Nanoscale Sciences and Technology and Biological Physics Research.

Experience

  • Adjunct Professor, Institute of Optoelectronic Sciences, National Taiwan Ocean University (2006,8 - present)
  • Associate Director, Research Center for Applied Sciences, Academia Sinica (2012 - present)
  • Adjunct Professor, Institute of Biophotonics Engineering, National Yang Ming University, Taiwan (2012 - )
  • Adjunct Professor, Department of Photonics, National Sun Yat-sen University, Taiwan (2015,8 - present)
  • Acting Executive Officer, Thematic Center for Mechanics and Engineering Science, Academia Sinica (2009,7 - 2015,12)
  • Research Fellow, Academia Sinica (2009,2-)
  • Associate Research Fellow, Academia Sinica (2004-2008)
  • Assistant Research Fellow, Academia Sinica (2000-2004)
  • Postdoctoral Fellowship, Academia Sinica (1996,1998)

Patents:

魏培坤、李光立,“非標定型感應晶片及其應用” 中華民國專利（發明I547373號）（2016/9/1-2034/9/1）
魏培坤、李光立,“非標定型檢測系統及其應用” 中華民國專利（發明I537550號）(2016/6/11-2034/3/6);
魏培坤、李光立, "奈米狹縫結構", 中華民國專利 發明 第I 397586號 2013, 6/1 - 2028,1/28
魏培坤、李光立,“非标定型感应芯片及鉴定化学物质的方法”中國大陸 專利 ZL 2014 0471384.5 (2017 2/15-2037 2/15
US patent, "Color light guide panel and liquid crystal display", Pei-Kuen Wei, Yeong-Der Yao, Da-Hua Wei, Shen-Yu Hsu, Kai-Wen Cheng, Tzu-Pin Lin, Chi-Neng Mo專利號： 8186865
TW patent (26A-930728) “平面光學消逝波微型陣列讀取系統” Pei-Kuen Wei (2006,10~2025, 11)
Pei-Kuen Wei, “Method and system for reading microarrays”, Publication Application No. US20060186346
TW patent ”奈米光纖探測器”, Pei-Kuen Wei and Yi-Chun Chen, TW1246995, Jan. 11, 2006
US patent “ Etching method for fabricating high quality optical fiber probe”, Pei-Kuen Wei and Yi-Chun Chen, US 6,905,627B2, Jun. 14, 2005
US patent “Large Area Scanning Tip System For Near Field Microscope ”。Pei-Kuen Wei and Wun-shain Fann. Period： 2001,8~ 2018,12，No. US 6,271,513B1。
Taiwan patent： “可進行大面積掃瞄之剪力回饋架構、利用此架構形成之近場光學顯微鏡”。發明人：魏培坤，范文祥。專利權人：行政院國家科學委員會, period：2000,7~ 2018,9，No：117513。

Publications

Recent Publications (2012-2017)

1. Kuang-Li Lee, Po-Cheng Tsai, Meng-Lin You, Ming-Yang Pan, Xu Shi, Kosei Ueno, Hiroaki Misawa, Pei-Kuen Wei*, 2017, “Enhancing Surface Sensitivity of Nanostructure-Based Aluminum”, ACS omeaga, 2, 7461-7470. (SCI)
2. Kuang-Li Lee, Hsuan-Yeh Hsu, Meng-Lin You, Chia-Chun Chang, Ming-Yang Pan, Xu Shi, Kosei Ueno, Hiroaki Misawa & Pei-Kuen Wei*, “Highly Sensitive Aluminum-Based Biosensors using Tailorable Fano Resonances in Capped Nanostructures”, Scientific Reports 7, Article number： 44104 (2017)
3. Ming-Yang Pan, Kuang-Li Lee, Likarn Wang, Pei-Kuen Wei*, “Chip-based digital surface plasmon resonance sensing platform for ultrasensitive biomolecular detection”, Biosensors and Bioelectronics, 91, May 2017, Pages 580-587
4. En-Hung Lin, Wan-Shao Tsai, Kuang-Li Lee, Ming-Chang M. Lee and Pei-Kuen Wei*, "Enhancing angular sensitivity of plasmonic nanostructures using mode transition in hexagonal gold nanohole arrays." Sensors and Actuators B： Chemical 241 (2017)： 800-805.
5. Tzyy-Jiann Wang, Hsi-Yang Hsu, Hsuan-Wei Chang, Hai-Pang Chiang, Yi-Ru Li, and Pei-Kuen Wei, 2017, “Electrostatic-field-tunable ferroelectric template for photoreduction of silver nanostructures applied in Raman scattering enhancement”, OPTICAL MATERIALS EXPRESS, Vol. 7, Issue 8, 2838-2846.
6. Tsung-Yeh Wu, Hsuan-Yeh Hsu, Kuang-Li Lee, Sen-Yeu Yang, Pei-Kuen Wei*, “Development of radio-frequency heating-assisted nanoimprint with PETG solution for nanostructure-based biosensors”, AIP Advances 7 No. 4, 045311 (2017)
7. Kuang-Li Lee, Tsung-Yeh Wu, Hsuan-Yeh Hsu, Sen-Yeu Yang, Pei-Kuen Wei*, “Low-Cost and Rapid Fabrication of Metallic Nanostructures for Sensitive Biosensors Using Hot-Embossing and Dielectric-Heating Nanoimprint Methods”, Sensors 17, 1548 (2017)
8. Shu-Cheng Lo, En-Hung Lin, Pei-Kuen Wei and Wan-Shao Tsai, “Compact Imaging Spectroscopic System for Biomolecular Detections on Plasmonic Chips”, Analyst, 2016, 141, 6126 - 6132
9. Kuang-Li Lee, Chia-Chun Chang, Meng-Lin You, Ming-Yang Pan, Pei-Kuen Wei*” Enhancing the Surface Sensitivity of Metallic Nanostructures Using Oblique-Angle-Induced Fano Resonances”, Scientific Reports 6, 33126 (2016)
10. Yi-Hsin Tai, Ming-Yang Pan, En-Hung Lin, Ding-Wei Huang and Pei-Kuen Wei*“Quality Detection of Alcoholic Beverages Using Optical Fiber Tips”, IEEE Sensors, 16, 5626-5631 (2016)
11. Yang, TH; Harn, YW ; Pan, MY; Huang, LD; Chen, MC; Li, BY ; Liu, PH; Chen, PY; Lin, CC; Wei, PK; Chen, LJ; Wu, JM “Ultrahigh density plasmonic hot spots with ultrahigh electromagnetic field for improved photocatalytic activities”, Applied Catalytic B-Environmental, 181, 612-624 (2016)
12. Sheng-Hann Wang, Chia-Wei Lee, Fan-Gang Tseng, Kuo-Kan Liang and Pei-Kuen Wei,*“Evolution of Gold Nanoparticle Clusters in Living Cells Studied by Sectional Dark-Field Optical Microscopy and Chromatic Analysis”, J. Biophotonics 9, No. 7, 738-749 (2016)
13. Wei-Chiao Huang, Pierre-Alain Burnouf, Yu-Cheng Su, Bing-Mae Chen, Kuo-Hsiang Chuang, Chia-Wei Lee, Pei-Kuen Wei, Tian-Lu Cheng, and Steve R. Roffler, ”Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells”, ACS Nano (2016) 26;10(1)：648-62.
14. Kuang-Li Lee, Meng-Lin You, Chia-Hsin Tsai, En-Hung Lin, Shu-Yi Hsieh, Ming-Hsun Ho, Ju-Chun Hsu, Pei-Kuen Wei*, ”Nanoplasmonic biochips for rapid label-free detection of imidacloprid pesticides with a smartphone” Biosensors and Bioelectronics, 75, 88-95 (2016)
15. Kuang-Li Lee, Meng-Lin You, Cheng-Lin Tsai, Chia-Yu Hung, Shu-Yi Hsieh and Pei-Kuen Wei*, “Visualization of biosensors using enhanced surface plasmon resonances in capped silver nanostructures”, Analyst 2016,141, 974-980
16. Yi-Hsin Tai, Dao-Ming Chang, Ming-Yang Pan, Ding-Wei Huang and Pei-Kuen Wei*, “Sensitive Detection of Small Particles in Fluids Using Optical Fiber Tip with Dielectrophoresis” Sensors 2016, 16(3), 303
17. Sheng-Hann Wang, Chia-Wei Lee, Kun-